【摘 要】
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Vascular smooth muscle cells (VSMCs) are important origin of foam cells besides macrophages.Mechanisms underlying VSMC foam cell formation are relatively little known.Activation of transient receptor
【机 构】
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第三军医大学大坪医院神内一科 400042
【出 处】
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第七届中华医学会神经病学分会全国中青年神经病学学术大会暨第十届全国神经系统感染性疾病与脑脊液细胞学学术大会
论文部分内容阅读
Vascular smooth muscle cells (VSMCs) are important origin of foam cells besides macrophages.Mechanisms underlying VSMC foam cell formation are relatively little known.Activation of transient receptor potential vanilloid subfamily 1 (TRPV1) and autophagy have potential role in regulating foam cell formation.Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs.This study provides evidence that autophagy plays important role in VSMC foam cell formation and highlights TRPV1 as a promising therapeutic target in atherosclerosis.
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