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  5. APP and its β-C-terminal fragment induce endosomal dysfunction and disrupt neurotrophic signaling

APP and its β-C-terminal fragment induce endosomal dysfunction and disrupt neurotrophic signaling

来源 :The 6th FAONS Congress and 11th Biennial Conference of CNS(第 | 被引量 : 0次 | 上传用户：t123
【摘 要】
：
Disruption of endosome-mediated signaling and trafficking of never growth factor(NGF)is believed to contribute prominently to atrophy and degeneration of basal forebrain cholinergic neurons(BFCNs)in A
【作 者】
：
Wei Xu Xinyi Wang Fang Fang Liang Liang Chengbiao Wu Jianqing Ding 
【机 构】
：
Department of Neurology,Shanghai Jiaotong University School of Medicine Ruijin Hospital
【出 处】
：
The 6th FAONS Congress and 11th Biennial Conference of CNS(第
【发表日期】
：
2015年3期
【关键词】
：
APP/β-CTF early endosome Rab5 Alzheimer's disease NGF signaling Basal foreb 
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　　Disruption of endosome-mediated signaling and trafficking of never growth factor(NGF)is believed to contribute prominently to atrophy and degeneration of basal forebrain cholinergic neurons(BFCNs)in Alzheimers Disease(AD)and in Down syndrome(DS).
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