MTA3 and the Mi-2/NuRD complex regulates EMT in esophageal squamous cell carcinoma through chromatin

来源 :2012医学科学前沿暨第二届个体化治疗与抗肿瘤药物研究新趋向研讨会 | 被引量 : 0次 | 上传用户：lyh198300

【摘要】

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【作者】

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Jinfeng Gan Weiwei Li Xiaoxuan Zheng lin Zheng Yuping Chen Hao Zhang

【机构】

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Cancer Research Center and Cancer Hospital,Shantou University Medical College,Shantou,Guangdong,Chin

【出处】

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2012医学科学前沿暨第二届个体化治疗与抗肿瘤药物研究新趋向研讨会

【发表日期】

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2012年11期

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　　Epithelial-mesenchymal transition (EMT) is a key regulator for morphogenesis during embryonic development and the essential contribution of the EMT to carcinoma progression is the loss of their epithelial characters,gain of mesenchymal marker expression,acquisition of migration,invasive activity and capability to pass through the basement membrane.Chromatin remodeling pathways are critical in the regulation of cancer-related genes and are currently being explored as potential targets for therapeutic intervention.

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MTA3 and the Mi-2/NuRD complex regulates EMT in esophageal squamous cell carcinoma through chromatin

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