【摘 要】
:
The development and metastasis of tumor is a multi-step process and involves a lot of genetic alterations.Cell adhesion molecule,E-cadherin is capable of ma
【机 构】
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Department of Genetics, China Medical University, North2nd Road,Heping District, ShenYang 110001
【出 处】
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2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)
论文部分内容阅读
The development and metastasis of tumor is a multi-step process and involves a lot of genetic alterations.Cell adhesion molecule,E-cadherin is capable of maintaining the polarity of epithelial cells and cell junction.Reduced expression of E-cadherin has been regarded as one of the main molecular events involved in dysfunction of the cell-cell adhesion system,triggering cancer invasion and metastasis.Loss of E-cadherin expression or function was observed in many gastric cancer cells.A direct role for E-cadherin in the suppression of tumor invasion has been demonstrated by the reversion of undifferentiated,invasive tumors to a differentiated phenotype after the transfection of E-cadherin cDNA in cell culture models.
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