Swimming exercise may not alleviate the depressive-like behaviors and circadian alterations of neuro

来源 :中国神经科学学会精神病学基础与临床分会第九届学术会议 | 被引量 : 0次 | 上传用户:stanley_lippman
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  Background: Many clinical studies have shown that circadian rhythmic abnormalities are strongly associated with major depression.Meanwhile a large number of researches have indicated that physical exercise could effectively reduce the stress impairment and improve ones mood, cognition and self-concept.Objective: We examined the effects of chronic unpredictable mild stress (CUMS) on rodent behaviors and the circadian rhythm of hormone and peptide levels in the Plasma.
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目的:探讨两种抑郁样模型大鼠脑Bold信号变化特征及SSRIs干预的效果.方法:用断奶前母婴分离(maternal separation,MS)和慢性不可预见的温和应激(chronic unpredictable mild stress,CUMS)结合孤养的方式建立两种抑郁样大鼠模型,予艾司西酞普兰10 mg/kg(i.p)干预,进行7.0Tmicro-MRI扫描,基于本研究组参与创建的利用SPM