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  5. Denitrosation Reaction versus Nitroso Group Migration in 6,-N-Disubstituted-N-Nitrosopyrimidin-4-Ami

Denitrosation Reaction versus Nitroso Group Migration in 6,-N-Disubstituted-N-Nitrosopyrimidin-4-Ami

来源 :The 24th International Society of Heterocyclic Chemistry Con | 被引量 : 0次 | 上传用户：wanghuayu1985
【摘 要】
：
An N-nitroso moiety can be used for the activation of chloropyrimidines towards nucleophilic substitution reaction with amines.The subsequent treatment of obtained products with aq.H2SO4 can lead eith
【作 者】
：
Inga Cikotiene Mantas Jonusis Virginija Jakubkiene 
【机 构】
：
Department of Organic Chemistry,Faculty of Chemistry,Vilnius University,Naugarduko 24,LT-03225,Vilni
【出 处】
：
The 24th International Society of Heterocyclic Chemistry Con
【发表日期】
：
2013年4期
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An N-nitroso moiety can be used for the activation of chloropyrimidines towards nucleophilic substitution reaction with amines.The subsequent treatment of obtained products with aq.H2SO4 can lead either to N-denitrosation to obtain 4,6-pyrimidinediamines, or to nitroso group migration and formation of 5-nitroso-4,6-pyrimidinediamines.The mechanistic aspects of the reactions together with scope and limitations will be discussed.
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