Candida albicans is a major opportunistic human fungal pathogen.Its pathogenicity is mainly caused by its capability of conversion between yeast and hyphae.This morphological conversion in C.albicans is regulated by multiple transcriptional regulators sensing many signal pathways.Spt-Ada-Gcn5-acetyltransferase(SAGA)complex is an evolutionarily conserved multifunctional transcription coactivator complex and plays a critical role in regulating transcription by modifying chromatin and identifying modification of histones.SAGA complex consists of five functional modules including histone acetyltransferase(HAT)module,deubiquitination(DUB)module,TATA-binding protein(TBP)regulatory module,structural module and transcriptional activator interaction module,which may be involved in the regulation of C.albicans morphogenesis.In this study,we focused on the functional roles of DUB module which consists of four components,Ubp8,Sgf73,Sus1 and Sgf11 in C.albicans.Deletion of the four components in DUB module compromised hyphal development.Each of them has different contribution to C.albicans morphologenesis.Our biochemical and morphological data demonstrates that the H2B deubiquitination is dynamically regulated via Ubp8 during transition of yeast and hyphae,and controls morphological plasticity of C.albicans.