Central IKKβ Inhibition Prevents Air Pollution Mediated Peripheral Inflammation and Exaggeration of

来源 :中国生理学会第24届全国会员代表大会暨生理学学术大会 | 被引量 : 0次 | 上传用户:wuchaoli87
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Background:Prior experimental and epidemiologic data support a link between exposure to fine ambient particulate matter (<2.5 μm in aerodynamic diameter,PM2.5) and development of insulin resistance/Type Ⅱ diabetes mellitus (Type Ⅱ DM).
其他文献
Objective:The purpose is to investigate the changes of nesfatin-1 expression in brain (hypothalamus) and peripheral tissues (gastric mucosa and plasma) during the pathophysiological course of type 2 d
Objective:The aim of this study was to explore serum betatrophin levels in health pregnant or gestational diabetes women,and patients with type 2 diabetes.We provided a better understanding of the phy
Background: Hypertension is a major risk factor for cardiovascular disease,a significant cause of worldwide morbidity and mortality.The association between adiponectin(APN,the most abundant secreted p
NMDA 受体是中枢神经系统内的离子型谷氨酸受体,近年研究显示,该受体亦广泛分布于多种外周非神经组织,包括胰岛细胞。研究报道,NMDA 受体的过度激活对神经和非神经组织具有毒性作用。本室前期研究发现在整体动物水平上,NMDA 受体的过度激活可损伤小鼠胰岛的功能。
PI3K/Akt 信号途径在细胞生理学的许多信号转导级联反应中起着重要的枢纽作用,然而蛋白激酶B(PKB/Akt)三个亚型的不同生理学功能尚不十分清楚。我们以前的研究报道了Akt 三个亚型在受精卵中的表达,本研究,我们观察了Akt1 和Akt2 在小鼠卵母细胞减数分裂恢复过程中定位及表达的区别。
The G protein-coupled estrogen receptor 1 (GPER1,also known as GPR30),is a Gs or Gi/o coupled GPCR and has been reported to bind 17β-estradiol (E2) to mediate the non-genomic estrogenic responses.GPER
Obesity is a low-grade chronic proinflammatory state,and adipose tissue is one of the insulin targets as the key link of obesity and insulin resistance.More than 50 %of the interstitial cells in adipo
罗格列酮是PPARγ的特异性激动剂,广泛用于Ⅱ型糖尿病的临床治疗。然而大量的临床研究显示,长期使用该药物的患者,其骨量丢失严重,骨折发生率显著提高。实验室研究也显示,罗格列酮能够抑制骨形成,然而具体作用机制尚未阐明。
Objective:Nesfatin-1,an anorexigenic peptide involved in energy homeostasis.Recently,peripheral nesfatin-1 was reported to participate in the development of T2DM and stimulated free fatty acid.The mai
Renal transplantation is the treatment of choice for end-stage renal failure.Although acute rejection is not a major issue anymore,chronic rejection is still a major factor that might lead to allograf