As an important delivery system,liposomes can enhance the stability,bioavailability and targeting of the preparation.Most commercial liposomal dosage forms in the market are lipophilic drugs,and less dosage forms are hydrophilic drugs.There are still few reports on the co-encapsulation of lipophilic and hydrophilic drugs.In our study,the biphasic nature of liposomes prepared by high pressure microfludization (HPM) was exploited to co-encapsulate a lipophilic drug (Medium chain fatty acid-MCFA) and hydrophilic drug (Vitamin C-Vit.C) in order to enhance their bioavailability.