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Introduction: Somatic mutations in the Ataxia-telangiectasia mutated (ATM) gene have been identified in a range of cancer types, including non-small cell lung cancer (NSCLC;5.1-9.1% of cases 1,2) and colorectal cancer (CRC;9% of cases 3).ATM is one of the central kinases involved in the cellular response to DNA damage, in particular to DNA double strand breaks.Loss of ATM function confers a high sensitivity to ionising radiation (IR) and topoisomerase inhibitors and may define a subset of lung cancer patients that could get increased benefit from these therapies.