S1P协同骨骼肌成肌细胞移植治疗大鼠急性心肌梗死的研究

来源 :中国生理学会第24届全国会员代表大会暨生理学学术大会 | 被引量 : 0次 | 上传用户：xq111

【摘要】

：

目的研究1-磷酸神经鞘氨醇(S1P)协同骨骼肌成肌细胞移植治疗急性心肌梗死的作用,为其临床应用打下基础。方法：结扎大鼠冠状动脉前降支建立急性心肌梗死模型,分别将无血清培养基、骨骼肌成肌细胞、导入S1P 的骨骼肌成肌细胞、导入脂质体的骨骼肌成肌细胞注射到梗死区,24 h 和48 h 后检测移植细胞的凋亡,4 周后检测心脏功能、心肌梗死面积变化,以阐明转基因骨骼肌成肌细胞对急性心肌梗死的治疗作用。

【作者】

：

于欢赵勇

【出处】

：

中国生理学会第24届全国会员代表大会暨生理学学术大会

【发表日期】

：

2014年7期

【关键词】

：

S1P 骨骼肌成肌细胞细胞移植急性心肌梗死凋亡

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S1P协同骨骼肌成肌细胞移植治疗大鼠急性心肌梗死的研究

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