Wnt proteins are a large family of cysteine-rich secreted glycoproteins that play essential roles in tissue development.There are two types of Wnt proteins, including canonical and non-canonical membe
软骨内成骨是脊椎动物骨骼发育的主要方式,肥大型软骨细胞被认为是终末分化的软骨细胞,通过偶联软骨形成和骨形成过程而在骨骼发育中起到"引擎"的作用.一个世纪以来,针对肥大型软骨细胞的最终命运这一重要科学问题一直存在争议,主流观点认为凋亡是其最终归宿.但因为缺乏确凿的体内遗传学证据,该争议始终未有定论.
To understand the molecular mechanism of anuran amphibian morphogenesis, here we sequenced three transcriptomes of distinct developmental stages (pre-metamorphosis, metamorphosis-climax and metamorpho
Paneth cells play a profound role in regulating intestinal microbiota and combatting enteric infection.Dysfunctional Paneth cells are often noted in patients suffering from inflammatory bowel disease
Cdc42, a member of the Rho GTPase family, plays critical roles in multiple cell functions, such as organization of the cytoskeleton, cell proliferation, cell polarity, and cellular transport.
Innate immunity mediated by Toll signalling has been extensively studied, but how Toll signalling is precisely controlled in balancing innate immune responses remains poorly understood.
Neutrophils are highly motile leukocytes that play important roles in the innate immune response to invading pathogens.Neutrophils rapidly migrate to the site of infections and kill pathogens by produ
Toll-like receptors (TLRs) are critical in mediating innate immune responses against infections.However,uncontrolled TLR-triggered inflammation is associated with endotoxin shock and tumors.We have re
Host pathogen-recognition receptors (PRRs) detect nucleic acid from invading viruses and initiate a series of signaling pathways that lead to the production of type Ⅰ interferons (IFNs) and pro-inflam
The emerging Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe pulmonary disease in human, and represents the second example of a highly pathogenic coronavirus followed SARS-CoV.