Objective Numb is first identified as a cell fate determinant in drosophila and is essential for maintaining neural stem cells during neurogenesis and promoting neuronal development.
Objective Depression is a pervasive mental disorder and a significant contributor to the global burden of disease,characterized by enduring sadness,loss of interest or pleasure,decreased energy or fee
Central histaminergic and orexinergic systems both originate in the hypothalamus restrictedly but innervate almost the whole brain,including various subcortical motor structures.