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Drugs have some common sources with foods and toxicants.Among xenobiotics, some characteristics in the aspect of the intracorporal process, toxic effect and action mechanism are all similar.Cytochrome P450 superfamily plays the pivotal roles in the metabolism of both endogenous substances and xenobiotics as well as endogenous steroidogenesis, and the status of fetal adrenal function development is key to decide fetal maturity and its fate after birth.