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防御素(defensins)是一类内源性抗微生物肽,广泛存在于生物体内。它不仅可以通过直接杀菌作用抵御入侵的病原微生物,而且还能介导获得性免疫反应、调节免疫炎性反应。其细胞毒性和细胞裂解活性在肿瘤免疫方面也起着重要作用。防御素已成为医学生物学和分子生物学研究的热点之一。作者综述防御素的抗菌活性、抗病毒活性、抗肿瘤活性及与疾病发生、发展的关系,并探讨其临床应用价值。
Defensins are a class of endogenous antimicrobial peptides that are found extensively in the body. It not only can resist the invasion of pathogenic microorganisms through direct bactericidal effect, but also can mediate adaptive immune response and regulate immune-inflammatory reaction. Its cytotoxicity and cell lysis activity also play an important role in tumor immunity. Defensins have become one of the hot topics in medical biology and molecular biology. The authors reviewed the antimicrobial activity of defensins, antiviral activity, anti-tumor activity and the relationship with the occurrence and development of disease, and to explore its clinical value.