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从H_(22)腹水癌细胞免疫小鼠脾脏提取的转移因子,在体外可抑制H_(22)癌胞内的cAMP—PDE(cAMP-磷酸二酯酶)活性,增加细胞内cAMP含量,降低cGMP/cAMP比值。其作用活性成分主要存在于Sephadex G-25柱层析后的Ⅱa、Ⅱb、Ⅲa和Ⅲb组分中。
The transfer factor extracted from the spleen of mice immunized with H_(22) ascites can inhibit the intracellular cAMP-PDE (cAMP-phosphodiesterase) activity, increase intracellular cAMP content, and reduce cGMP in H_(22) cancer cells. /cAMP ratio. The active ingredients mainly exist in the components of IIa, IIb, IIIa and IIIb after Sephadex G-25 column chromatography.