目的：观察中心静脉导管胸腔闭式引流合康莱特胸腔内灌注对肺癌恶性胸水的治疗作用。方法：将３０例支气管肺癌并中大量胸水的患者随机分为治疗组和对照组各１５例。治疗组予中心静脉导管胸腔闭式引流后再予康莱特胸腔内灌注；对照组予胸腔反复穿刺抽液后康莱特胸腔内灌注治疗。评价比较两组疗效，Ｋａｒｎｏｆｓｋｙ评分变化及毒副反应。结果：治疗组 ＣＲ３例，ＰＲ１０例，ＮＣ２例，有效率为 ８６．６７％，对照组无 ＣＲ，ＰＲ８例，ＮＣ７例，有效率为５３．３３％，两组疗效比较有显著性差异，两组Ｋａｒｎｏｆｓｋｙ标准评分治疗后无前提高，自身前后对照均有显著性差异，两组疗后Ｋａｒｎｏｆｓｋｙ标准评分疗后变化值比较有显著性差异。两组均无明显毒副反应。结论：中心静脉导管胸腔闭式引流合康莱特胸腔内灌注治疗对肺癌恶性胸水有较好的疗效，能提高病人的生活质量且无明显毒副反应，值得在临床上推广使用。 Objective: To observe the therapeutic effect of central venous catheter thoracic closed drainage combined with Kang Laite intrathoracic infusion on malignant pleural effusion of lung cancer. Methods: Thirty patients with bronchial lung cancer and a large amount of pleural effusion were randomly divided into treatment group and control group with 15 cases each. The treatment group received central venous catheter thoracic closed drainage followed by perfusion of KLT; the control group was treated with intrathoracic infusion of KLT after repeated puncture and drainage of the chest cavity. Evaluation of the efficacy of the two groups, Karnofsky score changes and toxic side effects. Results: In the treatment group, there were 3 cases of CR, 10 cases of PR, and 2 cases of NC2. The effective rate was 86.67%. There was no CR in the control group, 8 cases were PR, 7 cases were NC7, and the effective rate was 53.33%. There was a significant difference between the two groups. The group Karnofsky standard score did not improve before treatment, and there was a significant difference between the pre- and post-contrast controls. There was a significant difference in post-treatment Karnofsky standard scores after treatment. There were no obvious toxic side effects in both groups. Conclusion: Central venous catheter thoracic closed drainage combined with Kang Laite intrathoracic infusion treatment of lung malignant pleural effusion has a good effect, can improve the patient’s quality of life and no obvious toxic side effects, it is worth to promote the clinical use.