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Moutan Cortex is a well-known herb in traditional Korean,Chinese,and Japanese anti-diabetic formulae.In the current study,we investigated the metabolic effects of isolated triterpenes (1-7) in HepG2 cells under high glucose conditions.These compounds remakably stimulated AMP-activated protein kinase (AMPK),GSK 3β,and ACC phosphorylation.The compounds also increased glucose uptake and enhanced glycogen synthesis.Among these,compound 1 displayed the greatest potential anti-diabtetic activity though the AMPK activation pathway.Compound 1 significantly increased the levels ofphospho-AMPK,phospho-ACC,and phospho-GSK-3β and stimulated glucose uptake and glycogen synthesis in a dose-dependent manner.In conclusion,our results suggest that these compounds,especially compound 1,may have beneficial roles in glucose metabolism via the AMPK pathway.