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  5. Overcoming Tamoxifen Resistance of Human Breast Cancer by RNA Nanotechnology

Overcoming Tamoxifen Resistance of Human Breast Cancer by RNA Nanotechnology

来源 :The 6th International Conference on Nanoscience and Technolo | 被引量 : 0次 | 上传用户：qq414363439
【摘 要】
：
Over 70%of human breast cancer expresses estrogen receptor(ER)and selective estrogen receptor modulators(SERMs),such as tamoxifen,have been widely used in their treatments.Unfortunately,up to half of
【作 者】
：
Yijuan Zhang Marissa Leonard Peixuan Guo Xiaoting Zhang 
【机 构】
：
Department of Cancer Biology,University of Cincinnati College of Medicine,Cincinnati 45267,USA
【出 处】
：
The 6th International Conference on Nanoscience and Technolo
【发表日期】
：
2015年5期
【关键词】
：
RNA nanotechnology Tamoxifen resistance Estrogen receptor MED1 Breast Cancer 
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　　Over 70%of human breast cancer expresses estrogen receptor(ER)and selective estrogen receptor modulators(SERMs),such as tamoxifen,have been widely used in their treatments.Unfortunately,up to half of the patients are or soon become resistant to the therapy.Hence,further development of novel strategies to selectively block the activities of this pathway is urgently needed.
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