【摘 要】
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In order to determine the expression pattern of miR-101 in epithelial ovarian neoplasms and assess the functions and mechanism of miR-101 in tumorigenesis,we detected the expression of miR-101 and EZH
【机 构】
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Department of Obstetrics and Gynecology,Union Hospital,Tongji Medical College,Huazhong University of
【出 处】
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2014中国医师协会妇产科医师大会
论文部分内容阅读
In order to determine the expression pattern of miR-101 in epithelial ovarian neoplasms and assess the functions and mechanism of miR-101 in tumorigenesis,we detected the expression of miR-101 and EZH2 in normal,benign and malignant ovarian tissues,used miR-101 lentivirus infection to increase miR-101 expression in ovarian cancer cells and drug-resistant cancer cells.We found that miR-101 was underexpressed in epithelial ovarian cancer tissues,which significantly correlated with poor cell differentiation,advanced International Federation of Gynecology and Obstetrics (FIGO) stages and ovarian cancer cells cisplatin resistance.MiR-101 overexpression decreased the expression of EZH2,reduced proliferation and migration of ovarian cancer cells and resensitized drug-resistant cancer cells to cisplatin-induced cytotoxicity,suggesting the important role MiR-101 plays in ovarian cancer by targeting EZH2.Our findings show the potential of MiR-101 as a diagnostic marker and new therapeutic target for patients with epithelial ovarian cancer.
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