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  5. High level of IL-12 and gene polymorphisms in IL-12B on-6415CTCTAA/GC and rs3212227 were associated

High level of IL-12 and gene polymorphisms in IL-12B on-6415CTCTAA/GC and rs3212227 were associated

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：haihanzhi
【摘 要】
：
Aim: IL-12, a strong candidate gene for allergic diseases, can induce inflammation factors produced by natural-killer and T lymphocytes.This study was to investigate the possible roles of IL-12B-6415
【作 者】
：
Liang MING Qiang WEN Hai-ling QIAO 
【机 构】
：
Department of Clinical Pharmacology,School of Medicine,Zhengzhou University,Zhengzhou 450052,China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
IL-12 polymorphisms allergy penicillin 
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Aim: IL-12, a strong candidate gene for allergic diseases, can induce inflammation factors produced by natural-killer and T lymphocytes.This study was to investigate the possible roles of IL-12B-6415 (CTCTAA/GC) site in the promoter region and IL12B 3 untranslated region (UTR) (C/A), this SNP is now designated rs3212227 in penicillin allergy, and to explore the association between the polymorphisms of IL-12 gene and the levels of specific IgEs in penicillin allergy.
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