【摘 要】
：
To study the genetic mechanism of mental disorders, we developed several tools for the genetic data integration and analysis.One of the key efforts is to develop the series of genetic databases for at
论文部分内容阅读
To study the genetic mechanism of mental disorders, we developed several tools for the genetic data integration and analysis.One of the key efforts is to develop the series of genetic databases for attention deficit hyperactivity disorder (ADHDgene: Zhang et al., 2012, Nucleic Acids Research), major depressive disorder (MK4MDD: Guo et al., 2012, PloS One) and bipolar disorder (BDgene: Chang et al., 2013, Biological Psychiatry).These databases provide not only acomprehensive review of current genetic research but also high-confidence candidate genes and pathways for understanding of the disease mechanismsand shared etiology among the relevant diseases.
其他文献
AIM: To investigate the effects of ZD 7288, a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker, on rats with chronic visceral pain.METHODS: The visceral pain was evaluated by
The cerebellum participates in regulating nonsomatic visceral activities including food intake via the direct eerebellohypothalamic projections.The ventromedial hypothalamic nucleus (VMN) has traditio
Contribution of the vestibular end organ to regulation of arterial pressure was quantitatively compared with the role of baroreceptors in terms of baroreflex sensitivity and c-Fos protein expression i
肾上腺髓质嗜铬细胞分泌肾上腺素和去甲肾上腺素,通过作用于α-或β-肾上腺素能受体产生多种生理效应.已有研究表明α2-肾上腺素能受体调节肾上腺嗜铬细胞的分泌,但β-受体在肾上腺生长发育及生理功能中的作用仍不清楚.通过组织化学染色和放射性配体受体结合分析,检测肾上腺的大小、肾上腺皮质和髓质比例以及肾上腺嗜铬细胞的分泌,观察β受体基因敲除对肾上腺特别是肾上腺髓质的影响.结果显示成年的β1/2受体基因敲除
目的:本研究探讨4周中小强度有氧运动对大鼠心房肌蛋白质组差异表达的影响,筛选出心房肌中与有氧运动适应密切相关的目标蛋白质点,为慢性心血管疾病的运动康复研究提供新的思路及实验依据.方法:建立24m·min-1×40min运动强度负荷持续训练4周的有氧运动实验动物模型(负荷强度相当于60-70％VO2max).末次训练后6小时,取材并提取心房肌组织的全蛋白,采用双向凝胶电泳技术对蛋白质进行分离,运用B
目的:本文研究不同的运动条件下肌肉蛋白合成及降解的变化情况,为利用运动的方式促进蛋白合成,防治肌肉萎缩提供理论依据.方法:SD大鼠随机分成安静对照组(C组)、耐力训练组(E组)、抗阻训练组(R组)、后肢悬垂组(H组)、离心训练组(I组),进行8周不同方式的训练后,取腓肠肌,称取其重量,HE法测定骨骼肌细胞横截面积;免疫组化法测定p-AKT蛋白表达;免疫印迹法测定MuRF1、FoxO1的蛋白表达.
Decrease in endogenous hydrogen sulfide (H2S) was reported to participate in the pathogenesis of diabetic nephropathy (DN) This study is aimed at exploring the relationship among the abnormalities in
Diagnosis and treatment of mental illness may be advanced if one can measure brain activity from specific functional brain regions with high millisecond resolution with high reliability across time an
近来对大脑疾病的研究越来越关注于动物活体水平上神经环路的结构和活动的细节.在小动物神经系统成像领域目前应用较多的是双光子显微镜结合荧光成像的技术,但是成像深度已经无法满足研究者的需要.小动物光纤内窥镜成像技术是一种近年来刚刚发展成熟的,基于光纤束探头的激光共聚焦内窥镜成像技术,可以检测啮齿类动物任意深度的脑区.在此我们将介绍该技术的产生、原理、仪器设备的组成和应用范围.并以该技术在心理疾病中的应用
创伤后应激障碍(Posttraumatic stress disorder,PTSD)是因个体暴露异乎寻常的威胁性、灾难性事件后所发生的一种持续的,严重的心理疾患。已有研究表明,遗传因素在PTSD的发生中起到重要的作用。但是目前有关PTSD的分子遗传学研究相对较少,且研究发现的结果并不一致。基于先前的研究,本研究选取色氨酸羟化酶2 (TPH2)基因常见的单核苷酸多态性(SNP)位点(rs11178