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Dendritic cells (DCs) are professional antigen-presenting cells (APCs) and have an major role in the activation of T-cell-mediated immune responses.A water-soluble hydrolysate with immunomodulatory activity was obtained by cellulase degradation of shrimp chitosan.A low-molecular-weight chitosan (LMWC,molecular weight 20 kD)and the chitooligosaccharide mixture (oligomixture,containing sugars with 1 ~ 7 DP) were separated from a chitosan hydrolysate.