【摘 要】
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As a well-known toxic air pollutant,SO2 displays broad and complex toxicological effects,including oxidative damage,deoxyribonucleic acid(DNA)damage,changes in ion channels and signal transduction as
【机 构】
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Institute of Advanced Materials(IAM),Nanjing Tech University,Nanjing,211800
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As a well-known toxic air pollutant,SO2 displays broad and complex toxicological effects,including oxidative damage,deoxyribonucleic acid(DNA)damage,changes in ion channels and signal transduction as well as membrane damage.In contrast to its toxic effects,endogenous SO2 has antioxidant,anti-inflammatory,antihypertension and anti-atherogenic effects in mammals1.Therefore,SO2 may have a dual role in regulating physiological and pathophysiological effects in mammals.2 Herein,a glutathione responsive sulfur dioxide donor has been introduced into a BODIPY core(BODS)3,which possesses the dual functions of fluorescence imaging and gas release.We utilized a pH responsive amphiphilic polymers PEG-PAE to improve the biocompatibility of nanoparticle which also enhanced the lysosomal escape of the nanodrug.Upon the pH stimulation of tumor environment(TEM),PEG-PAE micellar swelling and releasing the BODS,which immediately reacted with the relative high concentration GSH in TEM and the fluorescence recovered by cutting off photo induced electron transfer.As generated SO2 could result in the enhancement of ROS generation and then induce the tumor apoptosis.Based on this,we would further investigate the generation mechanism of ROS in cell.Besides,we would also analyze the result of macrophage polarization and assess the efficacy in vivo 4.
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