Identification of a novel Kv1.3 antagonist from the venom of the spider Macrothele raveni

来源 :第12届生物毒素研究及医药应用学术大会 | 被引量 : 0次 | 上传用户：seankkk2000

【摘要】

：

　　The Kv1.3 voltage-gated potassium channel regulates membrane potential and calcium signaling in human effector memory T cells that are key mediators of auto

【作者】

：

BoChen;MinzhiChen;XiZhou;SongpingLiang;PingChen;ZhonghuaLiu;

【机构】

：

College of Life Sciences, Hunan Normal University, Changsha, Hunan

【出处】

：

第12届生物毒素研究及医药应用学术大会

【发表日期】

：

2015年期

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　　The Kv1.3 voltage-gated potassium channel regulates membrane potential and calcium signaling in human effector memory T cells that are key mediators of autoimmune diseases such as multiple sclerosis, type 1 diabetes, and rheumatoid arthritis.Thus, subtype-specific Kv1.3 blockers have potential for treatment of autoimmune diseases.

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Identification of a novel Kv1.3 antagonist from the venom of the spider Macrothele raveni

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