【摘 要】
:
The neural development is controlled by a tight coordination among cell proliferation,survival, and differentiation.Before final differentiation, the prolif
【机 构】
:
Department of Bioscience and Biotechnology, National Taiwan Ocean University,Keelung, Taiwan
论文部分内容阅读
The neural development is controlled by a tight coordination among cell proliferation,survival, and differentiation.Before final differentiation, the proliferating neural progenitor cells exit from cell cycle to elicit novel program leading to a specialized cell type.The proneural bHLH transcription factors, including Neurogenins and NeuroD family, play critical roles in neural differentiation by activating a core set of neurogenesis-related targets to orchestrate neuronal cell cycle arresting, differentiation and migration.In addition to NeuroD, the anti-apoptotic protein Survivin/Birc5 is also required for the developing neural cells.Knockdown birc5a or-5b abrogated NPC maturation and induced severe apoptosis.However, the mechanism of this Birc5a-mediated neural cell differentiation still remains unclear.Here we demonstrated that neurod1/-d4 and birc5a act coordinately in CNS development.Depletion of neurod1/-d4 abrogated birc5a transcription and induced massive NPC apoptosis.Likewise, knockdown birc5a resulted in neurod1 and neurod4 repression and arrested CNS development.The repealed neurogenesis induced by neurod1/-d4 depletion were rescued partially by ectopic birc5a mRNAs, indicating that neurod1/-d4 and birc5a act coordinately on NPC differentiation.
其他文献
Alternative polyadenylation (APA) is a widespread phenomenon that generates transcript isoforms with alternative 3UTR.Through alteration of 3UTRs, APA poten
Although efficient nonsurgical transfer of embryos in mice would provide many advantages over a surgical method, the low success rate of nonsurgical transfe
Several psychiatric disorders are associated with aberrant white matter development,suggesting oligodendrocyte and myelin dysfunction in these diseases.Radi
Chemical approaches have been used in analyzing biological systems such as enzyme inhibitors/activators, substrates, molecular probes, and protein modifiers
Physical and chemical causes-induced bone marrow (BM) damage often leads to lethality due to neutropenia, thrombocytopenia and anemia, as well as infection
Abstract C-type natriuretic peptide (CNP) is a peptide hormone belonging to the family of natriuretic peptide and chiefly expresses in ovary.This study aime
Zebrafish (Danio rerio), first established as a model to study embryonic development,has rapidly emerged as a popular vertebrate model organism in last two
Objective: To investigate the effects of heat shock treatment on the survial of germ cell in mice.Methods: Eighteen C57 male mice were randomly divided into
Zebrafish heart regeneration occurs throughout life by activation of resident cardiomyocyte (CM) proliferation.Hearts of neonatal mice can regenerate for up
A mechanism of cardiac loop formation was investigated using a mathematical model,vertex dynamics that was extended to the model applicable to three-dimensi