基于核磁片段筛选鉴定BRG1 bromo结构域的小分子抑制剂

来源 :第十八届全国波谱学学术年会 | 被引量 : 0次 | 上传用户：qubinai

【摘要】

：

BRG1是染色质重塑复合物BAF/PBAF的核心水解酶亚基,其ATP水解酶结构域可以结合并水解ATP提供能量,使染色质重塑复合物结合到染色质上介导DNA从核小体上解离从而调节基因的转录.BRG1C-末端是一个组蛋白密码的reader结构域,它可以特异性的识别乙酰化修饰的赖氨酸,这个过程对于染色质重塑复合物结合到正确的染色质位点至关重要.

【作者】

：

汪娜陈晓高佳马荣生何伟阮科

【机构】

：

中国科学技术大学生命科学学院,安徽合肥 230027 清华大学药学院,北京 100084

【出处】

：

第十八届全国波谱学学术年会

【发表日期】

：

2014年4期

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