2. 您的位置
3. 首页
4. 会议论文
5. Systematic identification of CDC34 that functions to stabilizes EGFR and promotes lung carcinogenesi

Systematic identification of CDC34 that functions to stabilizes EGFR and promotes lung carcinogenesi

来源 :2019中国肿瘤学大会 | 被引量 : 0次 | 上传用户：a247114340

【摘 要】

：

Objective The ubiquitin(Ub)-proteasome system is the principal pathway for diverse intracellular protein degradation,and plays a critical role in carcinogenesis.The aim of this study is to systematica

【作 者】

：

Xinchun Zhao Zhou Guangbiao 

【机 构】

：

Chinese Academy of Medical Sciences Cancer Hospital

【出 处】

：

2019中国肿瘤学大会

【发表日期】

：

2019年7期

【关键词】

：

lung cancer ubiquitin pathway genes CDC34 EGFR 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Objective The ubiquitin(Ub)-proteasome system is the principal pathway for diverse intracellular protein degradation,and plays a critical role in carcinogenesis.The aim of this study is to systematically identify ubiquitin pathway genes that are critical to lung carcinogenesis.

其他文献

The value of ITSN1 mRNA in predicting the prognosis of breast cancer

会议

ITSN1HER2breast cancerprognosis

Mucin 17 inhibits the progression of human gastric cancer by limiting inflammatory responses through

Objective Gastric cancer is one of the most common and aggressive cancer types throughout the world.Most gastric cancer associates with dysfunction of the mucosal barrier in the stomach,the first line

会议

InflammationGastric cancerMUC17Survive

靶向BET蛋白抑制胶质瘤干细胞的自我更新能力和致瘤性

目的 胶质瘤干细胞是恶性胶质瘤复发及难治的重要原因。因此，寻找有效的抑制胶质瘤干细胞干性特征的靶向治疗方式，是目前研究的热点。本课题研究的BET 家族蛋白在肿瘤重要的信号分子转录过程中起重要调节作用。

会议

BRD4notch1胶质瘤干细胞

EZH2抑制剂GSK126诱导胶质瘤细胞自噬性凋亡的实验研究

目的 本研究旨在研究EZH2 抑制剂GSK126 诱导胶质瘤细胞自噬性凋亡的分子机制,为靶向EZH2 治疗胶质瘤提供科学依据方法 1.TCGA 数据库中分析EZH2 在胶质瘤组织中的表达以及与胶质瘤患者预后的关系；同时采用western-blot、免疫组化及qPCR 检测临床来源的胶质瘤组织标本中EZH2 的表达情况；2.体外实验中CCK-8 检测EZH2 抑制剂GSK126 对胶质瘤细胞株及原代

会议

EZH2胶质瘤自噬性凋亡miR-101mTOR

Anterior gradient 3 promotes breast cancer development and chemotherapy response

Objective Breast cancer is one of the most common cancers in women and has been a major cause for cancer death of women.In clinical work,breast cancer is classified into four molecule subtypes mainly

会议

anterior gradient 3breast cancerinvasive ductal carcinomaprognosischemothera

Long non-coding RNA expression identified by microarray analysis:the potential candidate biomarkers

Objective Melanoma is a rare,but fatal skin tumor,which is consisted of four main types: lentigo maligna melanoma(LMM),superficial spreading melanoma(SSM),nodular melanoma(NM),and acral lentiginous me

会议

Acral lentiginous melanomaLong non-coding RNA (lncRNA)Microarray analysisCo-e

长非编码RNA lnc-AIR募集PTBP1介导LDHA的可变剪切促进ER阳性乳腺癌芳香化酶抑制剂耐药

目的 第三代芳香化酶抑制剂(aromatase inhibitors,AIs)作为临床上绝经后雌激素受体(ER)阳性乳腺癌患者的一线用药,通过阻断内源性雌激素的产生而抑制癌细胞的失控增殖,其疗效优于他莫昔芬。然而临床上AIs 治疗的有效率仅为25％～45％。

会议

长非编码RNAER阳性乳腺癌芳香化酶抑制剂可变剪切

Macrophages reprogrammed by lung cancer microparticles promote tumor development via releasing IL-1β

目的 Despite macrophages are known to contributed for inhibitory immune microenvironment of tumor(tumor associated macrophages,TAMs),the origin and function of TAMs are remaining poorly understood.

会议

tumor microparticlesinterlukin-1βmacrophageinflammasometumorrepopulating cel

GPRASP1:A novel potential biomarker for neuroendocrine carcinoma

Objective Neuroendocrine Carcinoma(NEC)is a malignant cancer which prone to local recurrence and remote metastasis,patients with this type of cancer usually have a poor prognosis and very short overal

会议

BiomarkerNeuroendocrineGPRASP1

FOXM1-mediated Linc-ROR Regulates the Proliferation and Sensitivity to Sorafenib in Hepatocellular C

会议

linc-RORFOXM1miR-876-5pHCCsorafenibsensitivity