【摘 要】
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Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious pathogen thatcauses severe diseases in pigs and great economic losses to swine industry worldwide.Type I interferons
【机 构】
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China Agricultural University
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious pathogen thatcauses severe diseases in pigs and great economic losses to swine industry worldwide.Type I interferons (IFNs) play a crucial role in antiviral immunity.In the present study, we demonstrated that HP-PRRSV strain JXwn06 infection antagonized type Ⅰ IFN expression induced by poly(I∶C) in both porcine alveolar macrophages (PAMs) and blood monocyte-derived macrophages (BMo).Subsequently, we showed that the inhibition of poly(I∶C)-induced IFNβ production by PRRSV was dependent on the blocking of NF-κB signaling pathways.
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