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Natural cellular membrane-based biomimetic nanoparticles have gained widespread attention owing to their cell surface mimetic characteristics and tailored nanomaterial features.These hybrid nanocarriers show strong potential in all kinds of biomedicine application [1].Leukocytes are important immunity cells that play important role in phagocytosis and disease prevention.Herein,we developed novel methods for the contruction of biomimetic magnetosomes by camouflaging Fe3O4 magnetic nano-clusters(MNCs)with leukocyte membranes.Firstly,water dispersible Fe3O4 MNCs with controllable sizes were synthesized with polyethyleneimine(PEI)as surfactant.The positive charges exposed on the clusters were then used to bind leukocyte membrane fragments by electrostatic interactions.