【摘 要】
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Deregulated thermal factors have been frequently implicated in the pathogenesis of male infertility, but the molecular basis through which certain responses are directed remain largely unknown.We prev
【机 构】
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Department of Human Anatomy, Histology and Embryology, Fourth Military Medical University, Xi'an 71
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Deregulated thermal factors have been frequently implicated in the pathogenesis of male infertility, but the molecular basis through which certain responses are directed remain largely unknown.We previously reported that overexpression of exogenous Metastasis-associated protein 1 (MTA1) protects spermatogenic tumor cells GC-2spd (ts) against heat-induced apoptosis.
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铁离子是胚胎肾发育的必需生长因子。妊娠妇女铁离子缺乏可导致胚胎肾发育缺陷,出生及成年后通常逐渐表现为慢性肾病。近来,我们建立了模拟妇女妊娠前后铁离子缺乏的小鼠模型和细胞特异性Tfr1基因敲除小鼠模型。研究结果发现,小鼠孕期前后铁离子缺乏可导致胚胎小肾甚至无肾,具体表现为胚胎肾的输尿管芽容量、肾小球和近端小管数目减少近90％；特异性敲除胚胎肾间充质、肾单位前体或输尿管芽细胞的铁离子转运基因Tfr1,