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OBJECTIVE The aim of this study was to investi gate the protection of minocycline in chronic ischemic cerebral white matter injury.METHODS Adult male mice (C57BL/6strain) were subjected to right unilateral common carotid arteries occlusion (rUCCAO), and treated with minocycline (25 mg·kg-1)once a day for the following ways: D 0-35, D 0-3, D 0-7,D4-7, D4-14, D4-35, D 15-35, or DO-3 and D 15-35.Object recognition test, and Morris water maze test were per formed at 27 d and immunohistochemical analyses were per formed at 35 d after rUCCAO.RESULTS We found that ad ministration of minocychne D 0-35, D 0-3, D 15-35, or D 0-3 and D 15-35 significantly ameliorated the decrease of my elin basic protein (MBP) expression and cognitive impairment e valuated by object recognition test, and Morris water maze test after rUCCAO.