【摘 要】
：
Proteins of the IQGAP family display complicated and often contradictory activities in tumorigenesis.IQGAP 1 has well documented oncogenic potential and IQGAP2 has putative tumor-suppressive function.
【机 构】
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Department of Immunology, Peking University Health Science Center
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Proteins of the IQGAP family display complicated and often contradictory activities in tumorigenesis.IQGAP 1 has well documented oncogenic potential and IQGAP2 has putative tumor-suppressive function.IQGAP3 is the latest addition to this family and its role in cancer development remains to be defined.Here we demonstrate IQGAP3 expression is markedly increased in lung cancer tissues at both mRNA and protein levels.Overexpression of IQGAP3 promoted tumor cell growth, and migration and invasion, whereas knockdown of IQGAP3 exhibited opposite effects.
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