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  5. Insulin increased stability of atherosclerotic plaques by inhibiting TLR4-MyD88 in a PI3K-dependent

Insulin increased stability of atherosclerotic plaques by inhibiting TLR4-MyD88 in a PI3K-dependent

来源 :第11届中国介入心脏病学大会 | 被引量 : 0次 | 上传用户：xiezhen120
【摘 要】
：
Background Insulin exerted anti-inflammatory effects in ischemic/reperfused heart tissue through phosphatidylinositol3-kinase (PI3K)-Akt-dependent (PI3K-Akt) pathway, as shown in our previous studies.
【作 者】
：
YAN Hao MA Mei-juan LI Yan WANG Hai-chang GAO Feng 
【机 构】
：
Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an,Shaanxi,China
【出 处】
：
第11届中国介入心脏病学大会
【发表日期】
：
2013年7期
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Background Insulin exerted anti-inflammatory effects in ischemic/reperfused heart tissue through phosphatidylinositol3-kinase (PI3K)-Akt-dependent (PI3K-Akt) pathway, as shown in our previous studies.Toll-like receptor 4 (TLR4)signaling as a key regulator of inflammation is known to participate in the development of atherosclerosis.We hypothesized that insulin might increase the stability atherosclerotic plaques by regulating TLR4-mediated pathway.
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