E6AP介导溶酶体参与内皮缺血损伤中紧密连接蛋白降解调控机制

来源 :2016第十一届心血管药理专业委员会全国心脑血管药理学术会议 | 被引量 : 0次 | 上传用户：jianghui_one1

【摘要】

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目的:观察缺血条件下内皮细胞中E6AP蛋白表达水平变化,探究E6AP与溶酶体蛋白LAMP2A之间的相互作用,并以此为突破口进一步探索缺血损伤条件下,E6AP介导的溶酶体参与紧密连接蛋白降解途径的机制.方法:体外实验采用内皮细胞系通过糖氧剥夺(Oxygen-glucose deprivation,OGD)模拟缺血损伤,利用免疫印迹方法明确E6AP、LAMP2A、Cathepsin B及紧密连接蛋白水

【作者】

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张睿婷高银萍蒋权卢应梅陶蓉蓉韩峰

【机构】

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浙江大学医学院,浙江杭州浙江大学城市学院,医学院,浙江杭州

【出处】

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2016第十一届心血管药理专业委员会全国心脑血管药理学术会议

【发表日期】

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2016年11期

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E6AP介导溶酶体参与内皮缺血损伤中紧密连接蛋白降解调控机制

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