Objective To investigate the clinicopathologic features,the management,and the prognosis of villoglandular papillary adenocarcinoma (VGPA) of the uterine cervix.Case reportsWe present 4 new cases of VGPA of the uterine cervix.(1)The median age of 4 patients was 55 years (range 47-70 years),with all 4 patients stage 1b disease.(2) Human papillomavirus (HPV) infection was detected in 3 patients,mainly type 16.No Oral contraceptive use history was found in these cases.(3) 2 patients underwent radical hysterectomy with bilateral salpingo-oophorectomy plus bilateral pelvic lymphadenectomy,I patient underwent radical hysterectomy with bilateral pelvic lymphadenectomy,and the remaining one received simple total hysterectomy plus postoperative radiotherapy.(4) Of these,only one had been correctly diagnosed preoperativey.In 2 patients,the biopsy results had been interpreted as cervical adenocarcinoma,and in the other one,the biopsy result was cervical intraepithelial neoplasia(CIN).(5) All 4 patients represented cervical wall invasion,including inner 2/3 invasion in one patient.No lymphovascular space invasion or lymph node metastasis was detected.(6) The patients are alive and well,with no evidence of recurrent disease.The follow-up ranged from 49 to 83 (median,64) months.Conclusion VGPA is an uncommon type of cervical adenocarcinoma,characterized by its excellent prognosis.HPV infection is associated with the molecular pathogenesis of VGPA,while oral contraceptive use can be excluded.As its low preoperative diagnostic accuracy,frequently cervical wall invasion and concomitant lesions,conservative treatment strategies should be carefully considered.