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目的探讨系统性红斑狼疮(SLE)合并妊娠子代早产儿的临床特点,提高新生儿科医师对这部分早产儿的认识。方法收集2000年1月至2012年6月间SLE合并妊娠子代早产儿的临床资料进行回顾性分析,并与同期出生的除SLE合并妊娠子代早产儿以外的2308例早产儿住院期间并发症发生情况进行对比。结果 SLE合并妊娠子代早产儿共42例,女婴比例明显高于男婴,其中确诊新生儿狼疮综合征4例。新生儿感染为SLE合并妊娠子代早产儿最常见并发症(47.62%),其次为小于胎龄儿(28.57%),新生儿呼吸窘迫综合征(26.19%),新生儿窒息和先天性心脏病(均为14.29%),肺出血(4.76%);与同期收治的2308例早产儿合并新生儿感染(16.81%)、小于胎龄儿(13.21%)和先天性心脏病(5.16%)的发生率进行比较,差异均有统计学意义(均P<0.05);其他合并症的发生率在两组早产儿间比较差异均无统计学意义。结论 SLE合并妊娠子代早产儿易合并感染性疾病、小于胎龄儿及先天性心脏病,而呼吸方面并发症与同期其他早产儿相比无显著差异。
Objective To investigate the clinical features of preterm infants with systemic lupus erythematosus (SLE) complicated by gestational age, and to improve the understanding of neonatal pediatricians on this part of premature infants. Methods The clinical data of premature infants with SLE complicated with gestational age from January 2000 to June 2012 were retrospectively analyzed and compared with those of 2308 preterm infants with complications during the same period of life except premature infants with SLE complicated by gestational age Occurrence of the situation for comparison. Results There were 42 cases of preterm infants with SLE complicated by gestational age, the proportion of female infants was significantly higher than that of the male infants, of which 4 were diagnosed with neonatal lupus syndrome. Neonatal infection was the most common complication (47.62%) of preterm infants with SLE and gestational age, followed by infants with gestational age (28.57%), neonatal respiratory distress syndrome (26.19%), neonatal asphyxia and congenital heart disease (14.29%) and pulmonary hemorrhage (4.76%). The incidence of neonatal infection (16.81%), gestational age less than gestational age (13.21%) and congenital heart disease (5.16%) in 2308 preterm infants Rates were compared, the differences were statistically significant (all P <0.05); other complications in the incidence of premature children between the two groups showed no significant difference. Conclusions The premature children with SLE complicated by gestational age are more likely to have infectious diseases than those with gestational age and congenital heart disease. However, the respiratory complications are not significantly different from those of other premature children in the same period.