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5. Effect of abemaciclib(LY2835219)on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexp

Effect of abemaciclib(LY2835219)on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexp

来源 :2016医学科学前沿暨第四届个体化治疗与抗肿瘤药物研究新趋向研讨会 | 被引量 : 0次 | 上传用户：quixotic

【摘 要】

：

Multidrug resistance(MDR)is the major obstacle of the success in cancer chemotherapy.The overexpression of ATP-binding cassette(ABC)transporters,particularly ABCB1,ABCC1 and ABCG2,play a significant r

【作 者】

：

Tong Wu Zhen Chen Kenneth K.W.To Xiaona Fang Fang Wang Bin Cheng Liwu Fu 

【机 构】

：

Department of Oral Medicine,Guanghua school of Stomatology,Guangdong Provincial Key Laboratory of St

【出 处】

：

2016医学科学前沿暨第四届个体化治疗与抗肿瘤药物研究新趋向研讨会

【发表日期】

：

2016年10期

【关键词】

：

LY2835219 multidrug resistance ATP-binding cassette transporters ABCB1 ABCG2 

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　　Multidrug resistance(MDR)is the major obstacle of the success in cancer chemotherapy.The overexpression of ATP-binding cassette(ABC)transporters,particularly ABCB1,ABCC1 and ABCG2,play a significant role in mediating MDR by pumping anticancer drugs out from cancer cells.

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