【摘 要】
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Cyclooxygenases (COXs) and their prostanoid products play important roles in a diverse range of physiological processes, including in the immune system.Here, we provide evidence that COX-1 is an essen
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Cyclooxygenases (COXs) and their prostanoid products play important roles in a diverse range of physiological processes, including in the immune system.Here, we provide evidence that COX-1 is an essential regulator in early stages of B cell development.COX-1-deficient mice displayed systematic reduction in total B cells, which was attributed to the arrest of early B cell development from pro-B to pre-B stage.We further demonstrated that this defect was mediated through down-regulation of the Janus kinase/signal transducer and activator of transcription 5 (JAK/STAT5) signaling and its target genes, including Pax5, in COX-1-/-mice.
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