论文部分内容阅读
Glioblastoma(GBM)is a highly infiltrative and incurable primary brain tumor.Despite aggressive therapy,patients with GBM have a dismal prognosis with median survival of about 1 year.Tumor control is short lived,with the vast majority of patients progressing within 6 months of diagnosis.Tamoxifen(Tam)is a selective estrogen receptor modulator(SERM),and it has been shown to inhibit glioma cell proliferation and induce cell apoptosis in vitro and in vivo.