T-ALL中A20基因3'UTR突变研究

来源 :中国免疫学会第十届全国免疫学学术大会 | 被引量 : 0次 | 上传用户:benlums
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  目的:急性T淋巴细胞白血病(T-ALL)是T细胞异常克隆性增殖形成而恶性程度高和预后较差的血液肿瘤.T-ALL患者中T细胞免疫功能及其TCR信号分子异常,A20(肿瘤坏死因子α诱导蛋白3,TNFAIP3)作为NF-κB的负调控因子,参与对TCR信号的调控.
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