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Investigate the role of the Hb and the Ic in OSA and the functional relationship.Stimulating the INS of Wistar rats, and compared the results with the control group.Stimulation the INS caused respiratory disturbance, apnea, reduced pH and aggravated base deficit.The Ic reduced MHb neurons, increased LHb neurons.Stimulation of the Ic induces apnea similar as human.The Ic and Hb are linked.