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Purpose: To discuss a detail clinical pathway about 3-stage therapeutic process of a sequence obturators for maxillectomy through a typical clinical case Methods: There are 3 prosthodontic therapeutic stages for maxillectomy: 1.Surgical obturator stage(2 week perioperative period of maxillectomy),discussing with surgeon,impression and manufacture a surgical obturator before operation and place it intraoperative period.2.Interim obturator stage(from 1 week to 3 month postoperatively),2 obturators need to be used,one is the modified surgical obturator use soft liner material,another is the new interim obturator fabricated with artificial teeth.3.Definitive obturator stage(3 month after operation),natural teeth with clasps or implant abutment with attachment to be retentions of the obturator according to planning.Typical case report CB is male,age 63,who was diagnosed with a right maxillary sinus carcinoma need a right maxillectomy.He had experienced fully 3-stage therapeutic process of obturator prostheses.The evaluation items include the appearance,seal,phonation,retention and mastication functions.