Specific Identification of Drug Targets through Activity-based Protein Profiling and iTRAQ quantitat

来源 :The 9th Asian Biophysics Association Symposium (ABA2015)(第九届 | 被引量 : 0次 | 上传用户:victinfy
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Most drugs exert pharmacological effects through interaction with their target proteins.Therefore, drug target identification is a crucial step towards the understanding of the mechanism of drug action.It is also imperative to study the pharmacodynamics of a known drug, with an aim to discover the potentially unrevealed actions and thus refine its future clinical applications.Currently, drug-target identification is either through in vitro affinity chromatography-based approaches or in vivo activity-based protein profiling (ABPP) approaches.
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