【摘 要】
：
Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of cancer, but the results are still debatable.Therefore, we performed a systematic review to provide a more c
【机 构】
：
Department of Urology, The Affiliated Hexian Memorial Hospital of Southern Medical University,Guangz
【出 处】
：
CUA2015全国泌尿男生殖系统肿瘤专题会议(10th)暨2015年广东省医学会泌尿外科学学术年会
论文部分内容阅读
Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of cancer, but the results are still debatable.Therefore, we performed a systematic review to provide a more complete picture and conducted a meta-analysis to derive a precise estimation.We searched PubMed, EMBASE,EBSCO, Google Scholar and China National Knowledge Infrastructure (CNKI) databases until April 2014 to identify eligible studies.Thirty-one studies with cancer patients and controls were included in the meta-analysis.Overall, the polled analysis revealed that the T-786C polymorphism was significantly associated with increased cancer risk under multiple genetic models (C vs T: OR=1.135, 95%CI=1.048-1.228;CC vs TT: OR=1.278,95%CI=1.045-1.562;TC vsTT: OR=1.136, 95%CI=1.023-1.261;CC+TC vs TT: OR=1.159,95%CI=1.047-1.281;CC vs TC+TT: OR=1.204, 95%CI=1.003-1.447).G894T was associated with significant risk for females (TT vs GG: OR=1.414, 95%CI=1.056-1.892;TT vs GT+GG: OR=1.356, 95%CI=1.108-1.661)and for breast cancer (T vs G: OR=1.097, 95%CI=1.001-1.203;TT vs GG: OR=1.346, 95%CI=1.012-1.789;TT vs GT+GG: OR=1.269, 95%CI=1.028-1.566).Increased susceptibility was revealed for prostate cancer with 4a/b (oa vs bb: OR=1.338, 95%CI=1.013-1.768;aa+ba vs bb: OR=1.474, 95%CI=1.002-2.170).This meta-analysis indicated that the eNOS T-786C polymorphism is associated with elevated cancer risk;the G894T polymorphism contributes to susceptibility to breast cancer and cancer generally in females;and the 4a/b polymorphism may be associated with prostate cancer risk.
其他文献
Introduction Insulin-like growth factor-1 (IGF-1) is one of the growth factor families.We have confirmed gene transfer of IGF-1 and intracavernosal injection (ICI) of IGF-1 protein to the penis could
Introduction.We have confirmed the higher expression of insulin-like growth factor binding protein-3 (IGFBP-3) in corpus cavernosal tissues of old rat and it may implicate for erectile dysfunction (ED
目的 目前大量研究表明,肿瘤中存在极小部分的细胞与肿瘤的进展、耐药和复发等恶性行为密切相关,这类细胞统称为肿瘤干细胞.目前对于前列腺癌干细胞的常规富集方法为悬浮培养法,然而该方法培养成本比较高、时间比较长并且富集效率一般.因此,寻找新的富集前列腺癌干细胞的方法可以加快促进针对前列腺癌干细胞的诊断和治疗研究.方法 利用慢病毒将Oct-4,Sox2和klf-4同时导人前列腺癌细胞株PC-3和22RV1
Aim: High mobility group protein box1 (HMGB1) and its receptor-receptor for advanced glycation end products (RAGE) are pivotal factors in the development and progression of many types of tumor,but the
Aim: The deletion of chromosomal region 6q was commonly found in several types of human cancers,although the tumour suppressor genes (TSGs) located within this genomic region are not well established.
目的 前列腺癌是男性第二高发肿瘤,随着经济水平的增长,我国前列腺癌的发病率越来约高.早期前列腺癌可以通过手术进行根治性切除,但晚期前列腺癌往往只能通过去势治疗或者化疗延长寿命,但效果一般.而大量的研究表面,肿瘤干细胞的存在与晚期前列腺癌的转移和化疗耐药等密切相关.因此,针对前列腺癌干细胞的治疗或许可以大大延长晚期患者的寿命.方法 BBI608是被研究出来专门针对肿瘤干细胞的化疗药物,其分子靶点主要
目的 前列腺癌发病年龄多在60岁以上，发病率居欧美国家男性恶性肿瘤的首位，死亡率仅次于肺癌列第二位.我国前列腺癌的发病率明显低于欧美国家，但近年来也有逐渐增加的趋势，且发病年龄趋于年轻化.前列腺癌，特别是激素非依赖性前列腺癌任是目前的治疗难点，因此，寻找新的抗前列腺癌药物显得尤其重要.盐酸石蒜碱是水仙提取物中的一种生物碱，已被证明具有多种药理活性，其中包括抗肿瘤活性.本研究拟探讨盐酸石蒜碱对人前列
目的 观察小檗碱(Neutral sulfate Berberine,Ber)协同表柔比星(Epirubicin,Epi)促T24膀胱癌细胞凋亡的作用,并进一步探讨其机制.方法 培养T24膀胱癌细胞株,观察不同剂量、不同时间点Ber对Epi处理后T24细胞的活力变化,用细胞毒性检测试剂盒(Cell Counting Kit-8,CCK-8)测定各组细胞活力.观察Ber对Epi处理后T24细胞凋亡的
目的 探讨肿瘤干细胞相关分子标志物CD133、CD105、CD34、CD44、CD24在肾癌细胞系786-O中表达,并分析靶向药物索拉非尼对这些标志物表达影响.方法 采用FCM分别检测胞系中肿瘤干细胞相关标志物CD133、CD105、CD44、CD24、CD34的表达情况,然后选用10.0μM作为作用浓度对786-O肾癌细胞进行干预,再检测不同时间点(0h、24h、48、72h、96h)各种标志物
目的 探讨低于硬水标准的不同钙、镁浓度比例饮用水对相对高草酸尿症大鼠肾草酸钙结石形成及代谢的影响.方法 将42只SPF级雄性Sprague-Dawley大鼠随机分成7组(n=6)：空白组、模型组、高钙低镁组、中钙低镁组、低钙低镁组、低钙中镁组和低钙高镁组,其中空白组大鼠饮用纯净水,模型组大鼠饮用含0.1％乙二醇(EG)的配制水,高钙低镁组、中钙低镁组、低钙低镁组、低钙中镁组、低钙高镁组等各组干预大