RNAa调控抑癌基因IRX1活化的探索性研究

来源 :第五届中国小核酸技术与应用学术会议 | 被引量 : 0次 | 上传用户：harry810

【摘要】

：

RNAi技术已广泛应用于基因功能研究并有望逐步走向临床.随着对非编码RNA研究的深入发现,ncRNA不仅可通过RNAi致基因沉默,也能使某些基因表达上调,即RNAa.自2006年Li等在应用

【作者】

：

于颖彦

【机构】

：

上海交通大学医学院附属瑞金医院

【出处】

：

第五届中国小核酸技术与应用学术会议

【发表日期】

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2015年9期

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RNAi技术已广泛应用于基因功能研究并有望逐步走向临床.随着对非编码RNA研究的深入发现,ncRNA不仅可通过RNAi致基因沉默,也能使某些基因表达上调,即RNAa.自2006年Li等在应用靶向E-cadherin基因启动子区dsRNA(dsEcad-302,dsEcad-215)转染前列腺癌PC-3和DU-145细胞株发现使靶基因表达值明显上调以来,诞生了小RNA激活技术,此类小RNA分子被称之为saRNA.

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RNAa调控抑癌基因IRX1活化的探索性研究

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