Previous work has suggested that the selection of "orthogonal" columns can be predicted using the values determined from the hydrophobic-subtraction model.This presentation wilt briefly review the model and calculations while relating them to the phase selectivity in reversed-phase liquid separations.The empirical results of the hydrophobic-subtraction model will be used in the selection of appropriate stationary phases for specific phase-solute interactions, ultimately defining a simplified process for column selection.Additionally, selected terms and the respective contributions to solute retention will be explored for substituted alkyl and non-alkyl phases.This presentation will demonstrate how knowledge of reversed-phase (RPLC) column phases and phase-solute interactions can aid in choosing the most selective columns for column screening, solute confirmation, and methods development.