【摘 要】
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Objectives To describe hematological adverse events (AE) and explore predictors for dose reduction caused by hematological AE in patients with advanced fibrosis receiving pegylated interferon plus rib
【机 构】
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AIDS Research Laboratory, Second Xiangya Hospital
【出 处】
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中华医学会第六次全国艾滋病、病毒性丙型肝炎暨全国热带病学术会议
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Objectives To describe hematological adverse events (AE) and explore predictors for dose reduction caused by hematological AE in patients with advanced fibrosis receiving pegylated interferon plus ribavirin for chronic hepatitis C (CHC).Methods MEDLINE, EMBASE, Web of Science, and The Cochrane library were searched for randomized clinical trials and observational studies reporting hematological AE associated with pegylated interferon plus ribavirin for CHC in patients with stage 3 or 4 fibrosis.Qualified studies were reviewed to extract patients baseline characteristics, disease information, treatment information, and clinical outcomes including incidence and grade of hematologic AE, dose reduction and treatment discontinuation due to hematological AE, and sustained viral response (SVR).Single-arm meta-analysis based on random effects model was performed by including patients treated by standard doses of pegylated interferon plus ribavirin to estimate the risks of hematological AE, dose reductions, and treatment discontinuations caused by hematological AE.Meta-regression analysis was conducted to explore possible predictors for dose reduction due to hematological AE and the association between hematological AE leading to related dose reduction and SVR.
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