Alginate is known to be a pH sensitive,biodegradation natural hydrogel material with relatively low cost.[1] In this work,compartmentalized biomineralized alginate beads ranged from micro-to visible scales with thermal-and pH-responsive drug delivery properties have been prepared via a one-step method.Hollow multilayer microcapsules made of aliphatic poly(urethane-amine)(PUA)and sodium poly(styrenesulfonate)(PSS)were served as drug container to slow down the drug release.