Semen is a critical vector for HIV sexual transmission and harbors seminal amyloid fibrils that can markedly enhance HIV-1 infection.Semen-derived enhancer of viral infection (SEVI) is one of the best
Objective: Amyloid fibrils play an important role in microbial infection.For example, semen-derived amyloid fibril and β-amyloid fibrils can greatly enhance HIV infection.
The persistence of latent HIV-1 reservoirs in resting memory CD4+T cells is a major barrier on the path to achieve a cure for HIV even though antiretroviral therapy (ART).
Objective: Bone formation by osteoblasts and bone re sorption by osteoclasts contributes to the balance of bone remodelling.Most pathologic bone diseases are due to excess osteoclastic activity, leadi
Objective: To determine the effect of iguratimod, a novel DMARD, on bleomycin-induced lung fibrosis and describe the underlying mechanisms.Methods: Mice were anaesthetized and then intratracheally inj
Aims: Insulin resistance, a hallmark of type 2 diabetes, is associated with obesity.Obesity gives rise to a state of chronic, low-grade inflammation that contributes to insulin resistance.Obese adipos
Regulatory B cells (Breg) are immunosuppressive cells that protect immune responses that can result in uncontrolled inflammation.Multiple studies demonstrated that IL-10 is not just a maker for Breg i